Effect of high glucose on the expression of Toll-like receptor 4 and the signal pathway in renal tubular epithelial cells
- VernacularTitle:高糖对肾小管上皮细胞Toll样受体4表达及其信号通路的影响
- Author:
Manli LI
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4;
High glucose;
Proximal tubular epithelial cell
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of Toll-likereceptor 4 in the production of inflammatory factors in renal innate cells stimulated with high glucose by studying the effect of high glucose on the expression of TLR4 and its signal pathway. Methods:Western Blot analysis was taken to measure the expression of TLR4,and the combination of Western Blot and immunoprecipitation was used to analyze the correlation of TLR4 with MyD88. Results:High glucose upregulated the expression of TLR4 protein and activated MyD88-dependent pathyway in MCT cells. Conclusion:TLR4 is involved in the pathogenesis of diabetic nephropathy by playing a role in the production of inflammatory factors in renal innate cells stimulated with high glucose.
