The effects of hypoxia on invasion and angiogenesis of gastric cancer in vitro
- VernacularTitle:缺氧对胃癌细胞侵袭转移和血管形成的影响
- Author:
Junwen ZHANG
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Hypoxia;
Invasion and metastasis;
Angiogenesis;
Transforming growth factor-beta
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of hypoxia on the invasion ,metastasis,and angiogenesis of gastric cancer in vitro. Methods: MTT was used to study the effects of viability durng hypoxia on SGC-7901,The Boyden Chamber membrane invasion culture system was used to study invasion,metastasis,and angiogenesis. Immunocy tochemical staining was used to observe the change of TGF-?1. Resuts: In the membrane invasion culture system,the numbers of invading and migrating SGC-7901 cells were significantly higher in hypoxia group than in the control group (P
