The role of dimethylaminoethyl ginkgolide B mesylate on inhibiting platelet ag- gregation and release function
- VernacularTitle:甲磺酸胺银杏内酯B对PAF诱导家兔血小板聚集和释放产物的影响
- Author:
Hong LIU
;
Suhua PAN
;
Chengding LIU
;
Min WEI
;
Huiqin XU
- Publication Type:Journal Article
- Keywords:
dimethylaminoethyl ginkgolide B mesylate;
PAF;
platelet aggregation;
Ca2+;
TXA2;
PGI2;
rabbit
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the inhibiting effect and mechanism of dimethylaminoethyl ginkgolide B mesylate on platelet aggregation and release function.METHODS: The effect of dimethylaminoethyl ginkgolide B mesylate on inhibiting PAF-induced platelet aggregation was measured by turbidimetry method through giving rabbits dimethylaminoethyl ginkgolide B mesylate at different final concentration via i.v.for 5 days.The release of Ca2 + from PAF-induced platelet in rabbits was assayed with fluorospectrophotometry and the contents of TXA2 and PGI2 were measured by radio-immunity method.RESULTS: Three groups of dimethylaminoethyl ginkgolide B mesylate (1.95,3.90,7.80 mg/kg) had significant effect on inhibiting PAF-induced platelet aggregation in rabbits (compared to normal,P
