Treatment of experimental allergic conjunctivitis with musk eye drops in guinea pigs
- VernacularTitle:麝香滴眼液对实验变应性结膜炎的治疗研究
- Author:
Chengyong TANG
;
Yuanda ZHOU
- Publication Type:Journal Article
- Keywords:
musk eye drops;
allergic conjunctivitis;
IgE;
histamine
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the therapeutic effect and its mechanisms of musk eye drops on allergic conjunctivitis (AC) in guinea pigs.METHODS: AC was developed by intraperitoneal injection of a mixture containing Ovalbumin (OVA) and Al(OH)3 in guinea pig.Sixty guinea pigs with AC were randomly divided into 6 groups,i.e.,AC model group,three treated groups treated with musk eye drops in high,middle and low dosage,group treated with dexamethasone sodium phosphate eye drops.Together with solvent group as sixth group.After one week of administration,the changes of guinea pigs in symptoms,histamine and OVA-specific IgE concentration of ocular tissues,and morphological features of conjunctiva were observed under light microscopy.RESULTS: Compared with the vehicle group,the conjunctiva symptoms scale,histamine and OVA-specific IgE concentration of ocular tissues and morphological changes scale of conjunctiva of guinea pigs in the model group were fairly good.Compared with the model group,the ocular symptoms of guinea pigs in each of the musk eye drops treated groups showed relieved (P
