Study on Expression of ENaC and rBSCl of Kidney Tissue in Lung-Qi Deficiency Model Rats
- VernacularTitle:肺气虚证模型大鼠肾组织钠离子转运相关蛋白表达变化研究
- Author:
Deshan WANG
;
Zhe WANG
;
Dehong SHAN
- Publication Type:Journal Article
- Keywords:
Lung-Qi deficiency model;
ENaC;
rBSCl;
ALD;
ANP;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of lung and kidney in TCM by detecting the protein expression related to Na+ transportation in the kidney tissue of Lung-Qi deficiency model rats.Methods Lung-Qi deficiency model of rats were copied.Immunohistochemistry was applied to measure the expressions of ENaC and rBSCl in renal tubular epithelium.RIA was used to detect ALD and ANP levels in plasma and lung tissue.Results Compared with the control group,expressions of ENaC and rBSCl of renal tubule were upregulated markedly,ALD level increased and ANP level decreased obviously in the model group.Conclusion Lung can regulate the expressions of ENaC and rBSCl in the renal tubule by secreting ALD and ANP,which can regulate Na+ and water reabsorption in the renal tubule and then influence the water metabolism of the body.
