Effect of Fuke Zhixuexiaotong Keli on the Expression of MMP-9 and TIMP-1mRNA in Rats Model of Incomplete Puerperal Involution of Uterus
- VernacularTitle:妇科止血消痛颗粒对产后子宫复旧不全大鼠模型子宫MMP-9、TIMP-1mRNA表达的影响
- Author:
Jing ZENG
;
Zhaoling YOU
;
Yaping CHA
- Publication Type:Journal Article
- Keywords:
incomplete puerperal involution of uterus;
Fuke Zhixuexiaotong Keli;
rats;
matrix metalloproteinase-9;
tissue inhibitor of metalloproteinase-1
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of Fuke Zhixuexiaotong Keli in rats model of incomplete puerperal involution of uterus by detecting the expression of metalloproteinases-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in the uterine redintegration incomplete model.Methods Seventy-two SD female rats were randomly divided into 6 groups:blank group,model group,Chanfukang group,and high-,middle-,low-dose of Fuke Zhixuexiaotong Keli group.The model of incomplete puerperal involution of uterus was established,and MMP-9,TIMP-1 gene expression level in each group were detected by in situ hybridization detection of uterine tissue.Results The expression of MMP-9 and TIMP-1 could be successfully detected in each group.The expression of MMP-9 in model group was significantly higher than the control group,and the expression of TIMP-1 was lower.The mRNA of MMP-9 gene was significantly decreased in both high-,middle-and low-dose of Fuke Zhixuexiaotong Keli group and Chanfukang group(P
