Immunomodulatory Function of Antibiotics and Their Effects on Pulmonary Fibrosis
- VernacularTitle:抗生素的免疫调节作用及其对肺纤维化的影响
- Author:
Jiaping WANG
;
Hongzhen YANG
;
Zhuowei HU
- Publication Type:Journal Article
- Keywords:
antibiotics;
suppressive immune responses;
nystatin;
pulmonary fibrosis
- From:Space Medicine & Medical Engineering
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immuno-regulatory roles of antibiotics and their implication for pulmonary fibrosis.Methods The regulatory roles of antibiotics on the phenotypes of dendrite cells(DCs) and maturation of B lymphocytes in vitro were detected with flow cytometry.The roles of nystatin on pulmonary fibrosis in vivo were determined with bleomycin-induced acute injury model of mouse.Results Multiple antibiotics including nystatin apparently promoted the maturation of DCs and B cells,as well as subsequently promoted the polarization of Th2 cells through DCs.In addition,nystatin intensified bleomycin-induced pulmonary fibrosis.Conclusion Multiple antibiotics including nystatin induce suppressive immune responses and might aggravate pulmonary fibrosis like nystatin.
