Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis
- VernacularTitle:红景天对肺纤维化大鼠MMP-2与TIMP-1表达关系的影响
- Author:
Yuanyuan WANG
- Publication Type:Journal Article
- Keywords:
Integripetal rhodiola herb;
Pulmonary fibrosis;
Matrix metallipro teinase-2(MMP-2);
Tissue inhibitor of metalloproteinase-1(TIMP-1);
Extracellular matrix(ECM)
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of IRH on pulmonary fibrosis and its intervention mechanism.Methods:45 sprague-dawley rats were randomly divided into three groups.The model group and the intervention group were received endotracheal injection of bleomycln to induce pulmonary fibrosis,while the control group were received endotracheal injection of saline.From the second day the intervention group IRH were injected to the stomach,while the other two groups were injected saline instead.On the 7th day,14th day and 28th day the lungs were isolated.The expression of MMP-2 and TIMP-1 was detected by immunohistochemical method respectively.Results:There was only a very weak expression of MMP-2 and TIMP-1 in the control group,there was significantly higher level in model group compared with control group on the 7th day,14th day and 28th day.The IRH group was significantly lower than the model group with the same time points,though it was also obviously higher than the control group all over the period(P
