Vascular protective effect of fasudil after subarachnoid hemorrhage in rats
- VernacularTitle:法舒地尔对蛛网膜下腔出血大鼠血管保护作用的机制研究
- Author:
Xiaodong ZHANG
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Fasudil;
Cerebral vasospasm
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the vascular protective effects and mechanism of fasudil in rats after experimental subarachnoid hemorrhage.Methods:Forty-eight rats were divided into sham-operated control group,subarachnoid hemorrhage group and treatment group.Model induced by autologous blood injection into cisterna magna,and rats were killed on day 1,day 3,day 7 and day 14 after subarachnoid hemorrhage.Morphological change of basilar artery was observed by light microscopy,diameter and wall thickness of basilar artery were measured respectively.eNOS expression in basilar artery was detected by immunohistochemical SP method.Results:Vasospasm of basilar artery initiated on day 1,reached its peak on day 3,and mitigated on day 7 after SAH.eNOS expression decreased at each time point in SAH group.Compare with SAH group,diameter and wall thickness of basilar artery were significantly reduced on day 3 and day 7 in treatment group(P
