Hath1 expression is down-regulated in colon non-mucinous adenocarcinomas compared with the expression in normal colon mucosa
- VernacularTitle:相较正常结肠黏膜,Hath1在非粘液性结肠腺癌中的表达下调
- Author:
Daihua ZHU
- Publication Type:Journal Article
- Keywords:
Colon carcinoma;
Hath1 gene;
Etiology
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the Hath1 expression in colon non-mucinous adenocarcinomas.Methods:Sections of paraffinembedded tissues were used to investigate the goblet cell population of normal colon mucosa,mucosa adjacent colon cancer and colon cancer samples which came from 48 patients with colon non-mucinous adenocarcinoma.Hath1 and Muc2 expression in these samples were tested by immunohistochemistry,quantitative real-time reverse transcription-PCR and Western blot.Results:There were not any goblet cell to be found in colon cancr.The levels of Hath1 mRNA and Hath1,Muc2 mRNA and Muc2 were significantly down-regulated in colon cancer.Conclusion:The down-regulation of Hath1 expression may correlate with colon carcinogenesis.
