Influence of topiramate on amino acids neurotransmitter of cerebral cortex in rats with cerebral ischemia reperfusion injury and neuroprotective effect
- VernacularTitle:托吡酯对急性脑缺血后大鼠脑皮层氨基酸类神经递质含量的影响及神经保护作用
- Author:
Jiangbing LIU
- Publication Type:Journal Article
- Keywords:
Middle cerebral artery occlusion rats;
?-aminobutyric acid;
Glutamic acid
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the neuro protective effects of topiramate on the changes of the nerve function deficiency scores and the influence of it on the content of amino acids neurotransmitter of cerebral cortex of rats with cerebral ischemia.Methods:Male SD rats were subjected to right middle cerebral artery occlusion for 2h and reperfusied for 24 h.Rats in the treatment group were injected with topiramate suspl(8mg/ml,80mg/kg)at the begining of the artery occlusion and the reperfusion.The nerve function deficiency scores were measured.The infarct volume was evaluated through TTC staining.The content of amino acids of cerebral cortex was estimated by the method of high performance liquid chromatography(HPLC)with fluorescent detection.Results:The infarct volume was significantly reduced by 41.8% in the TPMtreated group compared with that in the control group.There were significant differences in the neurological impairment scores between the treatment group and the ischemia group.TPM significantly decreased the content of Glu(P
