Effect of moderate hypothermia on inflammatory cytokines levels in cerebrospinal fluid after severe traumatic brain injury
- VernacularTitle:亚低温治疗对重型颅脑创伤患者脑脊液中细胞因子水平的影响
- Author:
Dijian SHI
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Moderate hypothermia;
Cytokine
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To investigate the effect of moderatehy pothermia on tumor necrosis factor alpha(TNF-?),interleukin-6(IL-6) and intedeukin-8(IL-8)in cerebrospinal fluid(CSF)of patients with severe traumatic brain injury(STBI)and its clinical significance.Methods:Forty patients with severe traumatic brain injury were randomly divided into hypothermic group and control group.Inclusion criteria included Glasgow Coma Scale(GCS)score ≤8 and time of after injury to on admission must be within 6 hours.TNF-?,IL-6,IL-8concentrations of CSF were tested before and after hypothermic therapy by radioimmunoassay.Results:Levels of serum TNF-?,IL-6 and IL-8 were decreased more significantly in the moderate hypothermia group than the control group(P
