Studies on in vitro release characteristics of drug from ?-carrageenan/konjac glucomannan matrix tablet
- VernacularTitle:?-卡拉胶/魔芋胶骨架片的体外释药特性研究
- Author:
Yu ZHANG
;
Caiwei DU
;
Ling WANG
- Publication Type:Journal Article
- Keywords:
?-carrageenan;
konjac glucomannan;
sinomenine hydrochloride;
matrix tablet;
in vitro dissolution
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The drug release characteristics of ?-carrageenan/konjac glucomannan matrix tablet were elvated by in vitro dissolution experiment. METHODS: Sinomenine hydrochloride was used as model drug,the matrix tablet containing ?-carrageenan and konjac glucomannan as matrix material were prepared by wet granulation technique. Drug release and tablet erosion in different pH values,ionic strength of media and rotation speeds were studied by in vitro dissolution experiment. The data of drug release and matrix tablet erosion were confirmed in Peppas and zero order equation,respectively. RESULTS: Among the rate of drug release in different media,0. 1 mol/L HCl was the fastest,distilled water was the second,pH6. 8 PBS was the slowest. The rate of drug release decreased with increasing the ionic strength of media(P 0. 1). The rate of drug release increased with increasing the rotation speeds(P
