Preparation and dissolution test in vitro of matrine controlled porosity osmotic pump tablet
- VernacularTitle:苦参碱微孔膜渗透泵片的制备及体外释放度的考察
- Author:
Yu FANG
;
Bai XIANG
;
Zhenhua PAN
;
Zhiguo TIAN
- Publication Type:Journal Article
- Keywords:
matrine;
controlled porosity osmotic pump tablets;
release in vitro
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study prescription and process of matrine controlled porosity osmotic pump tablet (matrine CPOPT) and to inspect release property in vitro. METHODS: The orthogonal experiment was designed to screen prescription and process which were definited with the evaluation of release of tablet. RESULTS: The optimization of prescription was definited: osmotic agent consisted of mannitol and lactose with a ratio of 1 ∶ 1(g/g); weight of osmotic agent was 2 fold increase of matrine; the cellulose acetate in coating liquid accounted for 15% (g/g) of PEG 400; The release behavior of matrine CPOPT was coincident with zero-order rate equation well and characteristic of controlled-release. CONCLUSION: Matrine CPOPT has good controlled-release in vitro effect and experiments for further in vivo test are available.
