Studies on In-vitro Transdermal Permeability of Cyclovirobuxine D Ethosomes
- VernacularTitle:环维黄杨星D醇质体体外经皮渗透性研究
- Author:
Yang YU
;
Liling ZHOU
;
Xinguo LIU
- Publication Type:Journal Article
- Keywords:
CYCLOVIROBUXINE D;
ETHOSOMES;
LIPOSOMES;
IN-VITRO TRANSDERMAL PERMEABILITY
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the in-vitro transdermal permeability of cyclovirobuxine D ethosomes.Methods Ethosomes,liposomes,saturated aqueous solution and 35.5% saturated alcohol solution of cyclovirobuxine D were prepared.The in-vitro transdermal permeability of different kinds of preparations of cyclovirobuxine D was studied by in-vitro permeation experiments.Results Cyclovirobuxine D ethosomes enhanced transdermal flux rate of cyclovirobuxine D and the enhancement ratio was 8.85,superior to liposomes and saturate alcohol.The dermatic hold-up amount of cyclovirobuxine D in 35.5% saturated alcohol solution,liposomes and ethosomes was in a decreasing sequence.Conclusion Compared with the liposomes,the ethosomes can enhance the transdermal flux rate of cyclovirobuxine D,which could increase the systematic action of the drug.
