Effect of Stigma Maydis Aqueous Extract on Glucolipid Metabolism and Oxidative Stress in Type 2 Diabetic Rats
- VernacularTitle:玉米须水提物对2型糖尿病大鼠糖-脂代谢及氧化应激的影响
- Author:
Xianchun WEN
;
Li ZHOU
;
Xiaoming LI
- Publication Type:Journal Article
- Keywords:
stigma maydis aqueous extract;
type 2 diabetes mellitus;
oxidative stress;
STZ;
glucolipid metabolism;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of stigma maydis aqueous extract on glucolipid metabolism and oxidative stress in type 2 diabetic rats.Methods Male Sprague-Dawley rats were randomly divided into normal control group,model control group,positive control group(Metformin) and stigma maydis aqueous extract low,middle,high dose group.Type 2 diabetic rats model was induced by high-fat and high-sugar dietary feeds and streptozotocin(STZ) in all groups except the normal control group.After treatment of 8 weeks,automatic biochemistry instrument was applied to detecting the levels of fast blood glucose(FBG),triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) in serum.The levels of free fat acid(FFA),malonaldehyde(MDA) and superoxide dismutase(SOD) in serum were assayed by uv-vis spectrophotometer.Results Compared with model control group,after stigma maydis aqueous extract treatment,middle and high dose groups remarkably lowered the levels of FBG,FFA,TG and TC in dose-dependent manner(P
