Analysis of Utilization and Adverse Drug Reaction of Aminoglycoside Antibiotics in Our Hospital During 2005-2008
- VernacularTitle:2005～2008年我院氨基苷类药应用及不良反应分析
- Author:
Yingzhuo GUAN
;
Jiangtao LIU
- Publication Type:Journal Article
- Keywords:
Aminoglycoside;
Adverse drug reaction;
Drug utilization
- From:
Chinese Journal of Pharmacoepidemiology
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the use and adverse drug reaction of aminoglycoside antibiotics(AmAn) in our hospital during 2005-2008,and to valuate its rationality for reducing its adverse drug reaction.Methods:The data about AmAn's consumption quantity and consumption sum in our hospital were analyzed with the DDD method.Results:Etimicin dominated the first place among AmAn in our hospital,and replaced Gentamicin.The quantities of Netilmicin,Isepamicin and amikacin were stable.In the same period,the main adverse drug reactions were allergic-like reactions,skin rash,ototoxicity and local numbness.Conclusion:Careful selection according to etiology,genetics testing,stronger monitoring of blood concentration and rational dosage treatment will provide a good prospect in the use of AmAn for the multifaceted gram-negative bacteria infection.
