Preparation of curcumin liposome and preliminary study on its stability
- VernacularTitle:抗肝纤维化姜黄素脂质体的制备及初步稳定性考察
- Author:
Yi ZHAO
- Publication Type:Journal Article
- Keywords:
Curcumin liposome;
Reverse phase evaporation;
Orthogonal design;
Encapsulation efficiency;
Stability
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare curcumin liposome and investigate its stability.Methods:Curcumin liposome was prepared by the reversed-phase evaporation method and purified by exclusion chromatography with Sephadex-50.The optimum formation was selected by means of orthogonal design of experiment;Centrifugal acceleration experiment and determination of leakling ration were served to proved the liposome stability.Results:The optimum formula was as follows:the ratio of lecithin to drug was 60∶1;lecithin:cholesterol was 4∶1;pH of PBS was 6.5,ultrasonic time was 5min.The average entrapment efficiency for curcumin was 95.06%.Conclusion:The selected formulation and preparation technique of curcumin liposome is reasonable in prescription,practicable in techniques,high in encapsulation efficiency and good in stability.
