An analysis on the relationship between polymrhism of intron 2 in serotonin transporter and polymrhism of serotonin transporter gene and attempted suicide
- VernacularTitle:5-羟色胺转运体基因第二内含子及启动子区多态性与自杀未遂的关联分析
- Author:
Xuemei LI
- Publication Type:Journal Article
- Keywords:
Attempted suicide;
Genes;
Polymorphism(genetics);
Serotonin transporter(5-HTT)
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between attempted suicide and polymrhism of intron 2 in serotonin transporter and polymrhism of serotonin transporter(5-HTTLPR).Methods:Using the technique of polymerase chain reaction(PCR),the variable number of tandem repeat polymorphism(5-HTTVNTR)and 5-HTTLPR was determined in 71 patients with attempted suicide subjects and 80 control subjects.The allelic and genetypes distributions in two groups were compared.Results:There were no significant differences in intron 2-VNTR genotype and allele frequency distributions between attempted suicide and healthy control subjects(?2= 1.08,P=0.58;?2=0.99,P=0.32).The frequencies of allele S were significantly higher in suicides attempted suicide patients with psychiatric disorder(85.1%)than in normal controls(72.5%)and suicides without psychiatric disorde(r69.1%)(?2=4.49,P=0.04;?2=5.21,P=0.03).Conclusion:The results suggested that the polymrhism of intron 2 of 5-HTT gene no associated with attempted suicide in the Han nationality.But the presence of 5-HTTLPR alleles S may increase the risk for attempted suicide.
