Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice
- VernacularTitle:膜糖蛋白CD36缺失对小鼠胰岛素抵抗的影响
- Author:
Xian CHEN
- Publication Type:Journal Article
- Keywords:
CD36;
C57BL/6 mice;
CD36 knockout mice;
Insulin resistance
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether CD36 deficiency promotes insulin resistancein the C57BL/6 mice.Methods:Micewerefedwith a high-fat die(tn=7)for 14 weeks.Intravenous glucose tolerance tests,insulin release and tolerance tests were performed.Triglyceride and free fat acid levels in serum were measured.Results:Compared with the C57BL/6 mice,blood levels of glucose,insulin,triglyceride and free fatty acid were increased in the CD36 knockout mice.Conclusion:The CD36 deficiency indeed promotes insulin resistance in the C57BL/6 mice.
