Expression of integrin ?_2,?_3 and ?_5 in developing mouse kidney
- VernacularTitle:小鼠肾发育中整合素?_2、?_3及?_5的表达
- Author:
Shuling LI
- Publication Type:Journal Article
- Keywords:
Intergrin;
Mouse;
Kidney;
Development
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the chronological and spatial expressions of integrin ?2,?3 and ?5 which were the receptor of extracellular matrix(ECM) in the developing mouse kidney and investigate the correlation of integrin ?2,?3 and ?5 with kidney development.Methods:The expressions of integrin ?2,?3 and ?5 were examined by immunohistochemistry and stereological method.Results:The expressions of ?2,?3 and ?5 were observed from the kidney of E12d.The expression of integrin ?2 was little in the glomeruli,but obviously in renal tubules and collecting ducts,while the expression of intergrin ?3 was obviously in glomeruli.The expressions of integrin ?2,?3 and ?5 were increased gradually with kidney development by stereological analyses.Conclusion:It is suggested that integrin ?2,?3 and ?5 might play the important role in the kidney development of mouse.
