Effects of Electroacupuncture on Glucose Transporter-1 Expression of Hippocampal Microvascular Endothelial Cells in Rats with Focal Cerebral Ischemia
- VernacularTitle:电针对局灶性脑缺血大鼠海马微血管内皮细胞葡萄糖转运蛋白-1表达的影响
- Author:
Yan LU
;
Shijun WANG
;
Xiutao SONG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Electroacupuncture;
Microvascular endothelial cells;
Glucose transporter-1 expression
- From:
Acupuncture Research
2010;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture(EA) on the expression of glucose transporter-1(GLUT-1) of hippocampal microvascular endothelial cells in focal cerebral ischemia(CI) rats.Methods Sixty male Wistar rats were randomly divided into sham-operation,model and electroacupuncture(EA) groups.CI model was established by middle cerebral artery occlusion with a piece of thread embolus.EA(4 Hz/20 Hz,1 mA) was applied to bilateral "Neiguan"(PC 6) for 30 min,once daily for 15 days.GLUT-1 expression in the hippocampus was detected with immunohistochemistry and Western blot,respectively.Results After the treatment,compared with the sham-operation group,the expression of GLUT-1 in microvascular endothelial cells of the hippocampus in model group shown by both histochemical and Western blot techniques decreased apparently(P
