Observation on the Therapeutic Effect of Electroacupuncture Combined with Small Dose of Clozapine in Clinical Treatment of Refractory Schizophrenia
- VernacularTitle:电针联合小剂量氯氮平治疗难治性精神分裂症的疗效观察
- Author:
Dianzhang XIONG
;
Lingling LIU
;
Yan YI
;
Feng YE
- Publication Type:Journal Article
- Keywords:
Refractory schizophrenia;
Electroacupuncture;
Clozapine;
PANSS score;
TESS score
- From:
Acupuncture Research
2010;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture(EA) in combination with small dose of clozapine on clinical symptoms of refractory schizophrenia patients so as to evaluate its validity and security.Methods Eighty schizophrenia patients were randomized into medication group and EA+medication group(n=40/group).Patients of medication group were treated with conventional oral administration of clozapine(50-100 mg/d to 200-500 mg/d,for 8 weeks) and those of EA+ medication group treated by EA of Baihui(GV 20) and bilateral Taiyang(EX-HN 5) and oral administration of clozapine(50 mg/d to 100-150 mg/d).EA was given to the patients,3 times a week for 8 weeks.Scores of the Positive and Negative Symptom Scale(PANSS) and the Untoward Effect Symptom Scale(TESS) were used to assess the therapeutic effect.Results Following treatment,PANSS scores for positive symptoms and the common psychiatric symptoms of the medication and EA+medication groups all decreased evidently from the 2rd week on(P0.05).But TESS score of EA+medication group was evidently lower than that of medication group(P
