Research on preparation technology of ligustilide liposomes
- VernacularTitle:藁本内酯脂质体制备工艺的研究
- Author:
Zhihao LI
;
Peng LI
;
Xuesong ZHU
;
Fang ZHENG
- Publication Type:Journal Article
- Keywords:
ligustilide;
liposomes;
preparation technology
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription and preparation technclogy of ligustilide liposomes. Methods Ligustilide liposomes were prepared by ethanol injection method. The encapsulation efficiency was taken as inspection target and the preparation of liposomes was optimized by orthogonal design. HPLC was used to measure the encapsulation efficiency. Results The best prescription was ligustilide-lecithin (1:10),lecithin-cholesterol (2:1),the water phosphate buffer solution (pH 7.5),the hydration temperature was 35 ℃. Conclusion The optimized formulation of ligustilide is reasonable in prescription and practicable in technology.
