The value of the combined measurement of serum ?-HCG and VEGF for predicting early rupture of tubal pregnancy
- VernacularTitle:血清?-HCG联合VEGF早期诊断输卵管妊娠破裂的评价
- Author:
Qi SUN
- Publication Type:Journal Article
- Keywords:
?-Human chorionic gonadotropin;
Vascular endothelial growth factor;
Rupture of tubal pregnancy
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate serum ?-HCG and VEGF concentrations in women with rupture of tubal pregnancy(rTP),tubal abortion(TA) and spontaneous abortion(SA) at about 6 weeks of gestation.Methods:This was a prospective,case-control study evaluating serum ?-HCG and VEGF concentrations among 63 women with the symptom of abdominal pain or vaginal bleeding who subsequently were confirmed rTPs(n=21),TAs(n=14),SAs(n=27).One suspected TP proved to be normal intrauterine pregnancy and was excluded.?-HCG,and VEGF were measured by RIA and ELISA methods respectively.Results:The median ?-HCG concentrations in rTPs and TAs were statistically higher than that in SAs(3070.70?1069.68,2632.21?840.60,1674.05?727.88mIU/ml respectively,P1 880 mIU/ml,serum ?-HCG could discriminate TPs from SAs with a sensitivity of 88.6%,a specificity of 66.7% and a positive predictive value of 77.5%.The median VEGF concentration in rTPs was statistically higher than that in TAs and SAs(254.87?78.52,105.81?38.11,118.32?52.94 pg/ml respectively,P179pg/ml,serum VEGF could discriminate rTPs from TAs with a sensitivity of 85.7%,a specificity of 100% and a positive predictive value of 100%.Conclusion:It is a useful marker that the combined measurement of serum ?-HCG and VEGF predicts the rupture of tubal pregnancy at about 6 weeks of gestation.
