Effects of Different Compositions of Guanxin Ⅱ(GXⅡ)Prescription on Experimental Myocardial Infarct in Rats
- VernacularTitle:冠心Ⅱ号不同组分配伍对大鼠急性心肌梗死的影响
- Author:
Jinyan ZHANG
;
Yikui LI
;
Le ZHAO
;
Lianda LI
- Publication Type:Journal Article
- Keywords:
Guanxin Ⅱ prescription;
Compatibility of Traditional Chinese Medicine;
Myocardial infarct
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare effects of the whole prescription of Guanxin Ⅱ(GXⅡ),the hemorheologic agents and the Qi-regulating agents of the whole prescription on acute myocardial infarction in rats.Methods Acute myocardial infarct(AMI)model was established by coronary artery ligation,and then the model rats were treated with intraduodenal administration of different compositions of GXⅡ 5～10 minutes after the artery ligation.Five hours after modeling,blood was collected to determine the levels of endothelin(ET),thromboxane(TXB2),isoenzymes of creatine kinase(CK-MB)and andlactate dehydrogenase(LDH).The heart of rats was cut into five slices and dyed by nitrotetrazolium blue chloride(N-BT)for 5 minutes,and then the infarcted area(non-N-BT staining area)and the noninfarcted area(N-BT staining area)were detected.Results Compared to the model group,both the whole prescription of GXⅡ and the hemorheologic agents significantly reduced infarct size,ameliorated blood ET,TXB2,CK-MB and LDH levels(P
