Influence of Lycium Barbarum Polysaccharide on FasL Expression in H22-bearing Mice and Its Anti-tumor Mechanism
- VernacularTitle:枸杞多糖对实验性肝癌小鼠肿瘤细胞FasL表达的影响及其抗肿瘤作用机制
- Author:
Yanli HE
;
Biaoyan DU
;
Huifeng WANG
;
Ning SU
;
Xia XIAO
- Publication Type:Journal Article
- Keywords:
LYCIUM BARBARUM POLYSACCHARIDE/pharmacology;
LIVER NEOPLASMS/TCD therapy;
NEOPLASMS /pathology;
GENE EXPRESSION REGULATION;
DISEASE MODELS,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Lycium Barbarum polysaccharide(LBP) on FasL expression in H22-bearing mice and to explore its anti-tumor mechanism.Methods Kunming mice were randomized into the model group,and low-and high-dose LBP(in the dose of 0.625 and 1.250 g?kg-1?d-1 respectively) groups.H22-bearing mice models were induced through right subaxillary inoculation of H22-ascitic cells.Three days after inoculation,LBP group were given LBP for 14 days.Hematoxylin and eosin(HE) staining method was used to examine the tumor cell density,tumor cell mitotic count,and lymphocyte infiltration in tumor interstitial tissue.FasL expression was observed in the three groups with immunohistochemical method.Results Tumor cell mitotic count was decreased in the two LBP groups(P
