Experimental Study on In-vivo Effect of Compound Phyllanthus urinaria Ⅱ on Duck Hepatitis B Virus
- VernacularTitle:叶下珠复方Ⅱ号体内抗鸭乙肝病毒的实验研究
- Author:
Xiaoyue LI
;
Jinyang HE
;
Changqing LI
;
Junfang SU
;
Bozhen DONG
;
Xiangyang LI
- Publication Type:Journal Article
- Keywords:
COMPOUND PHYLLANTHUS URINARIA Ⅱ/pharmacology;
HEPATITIS B,CHRONIC/TCD therapy;
HEPATITIS B VIRUS,DUCK/blood;
VIRUS REPLICATION;
DISEASE MODELS,ANIMAL;
DUCKS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the in-vivo effect of Compound Phyllanthus urinaria Ⅱ(CPU Ⅱ) on duck hepatitis B virus(DHBV).Methods Thirty ducks with congenital infection of DHBV,which were DHBV-DNA positive confirmed by polymerase chain reaction(PCR),were randomly divided into 5 groups: DHBV control group,high-,middle-,and low-dosage CPU Ⅱgroups(in the dose of 33.6,18.6 and 8.4 g-1?d-1,respectively),and Lamivudine group(20 mg?kg-1?d-1).The serum DHBV-DNA level of all ducks was detected by quantity real-time fluorescence PCR before and after medication.Results On the 7th,14th,21st,and 28th day of medication and on the 5th day of suspension of medication,the serum DHBV-DNA level in both of the high-and middle-dosage CPU Ⅱ groups was obviously lower than that before medication and than that in the DHBV control group(P
