Evaluation on in vitro release of gastric floating sustained-release preparation of Tripterygium wilfordii by HPLC fingerprints
- VernacularTitle:指纹图谱评价雷公藤胃漂浮缓释制剂的体外释放度研究
- Author:
Wei ZHANG
;
Hongtao SONG
;
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii gastric floating sustained-release preparation;
HPLC fingerprints;
in vitro release
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug in vitro release behavior of gastric floating sustained-release preparation of Tripterygium wilfordii and establish their quality evaluating methods.Methods HPLC was Employed to gain the fingerprints of releasing medium of preparations.Triptolide was selected as marker to calculate the linear equation concerning peak area then the relative drug release and f2 simila-rity factor value were acquired.Results Various components in gastric floating sustained-release tablets and pellets of T.wilfordii could not release synchronously while sustained-releasing but all of them in the gastric floating sustained-release capsules of T.wilfordii prepared by using multiparticulate site-controlled release technology could release synchronously while sustained-releasing.Conclusion The quality and in vitro release behavior of gastric floating sustained-release preparation of T.wilfordii could be evaluated more scientifically and comprehensively by using HPLC fingerprints method.
