Effects of total glucosides of paeony on the expression of IFN-?,TNF-?and IL-10 in the rat model for chronic abacterial prostatitis
- VernacularTitle:白芍总苷对慢性非细菌性前列腺炎大鼠IFN-?、TNF-?和IL-10表达影响的实验研究
- Author:
Hongzhi WANG
- Publication Type:Journal Article
- Keywords:
Prostatitis;
TGP;
IFN-?;
TNF-?;
IL-10
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of TGP on IFN-?,TNF-?and IL-10 in prostatic tissue of CAP rats.Methods:40 aged sprague dawley rats were randomly divided into four groups:the control group(10 rats),the rat model for CAP group(10 rats),the rat model for CAP treated with low dose TGP group(10 rats)and the rat model for CAP treated with high dose TGP group(10 rats).The changes of prostate gland inflammation was investigated by HE stain.The expression of IFN-?and TNF-?in rat prostatic tissue was detected by immunohistochemistry(sp).The expression of IL-10 in rat prostatic tissue was detected by enzyme linked immunosorbent assay(ELISA).Results:(1)The changes in histopathology in the animal model were similar to those in clinical CAP and the inflammation of treatment group obvious change for the better;(2)The IFN-?,TNF-?and IL-10 in the rat model for CAP group were higher than the control group;(3)The IFN-?,TNF-?and IL-10 expression reduces along with the TGP dosage increases in the rat model for CAP (P
