Dermal toxicology and absorption of Triptolide Compound Cream
- VernacularTitle:雷公藤内酯醇复方乳膏剂皮肤毒理及其透皮吸收性能研究
- Author:
Zhenghai LONG
;
Dengming WEI
;
Jibin DU
- Publication Type:Journal Article
- Keywords:
Triptolide;
Compound Cream;
toxicology;
pemeability
- From:
Chinese Traditional Patent Medicine
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream.METHODS: 2% azone+1% volatile oil of twig from Camellia.oleifera was used as permeation enhancer to prepare Triptolide Compound Cream.Acute dermal toxicity,irritation a sensitization test on mouse were carried out.And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity,irritation or hypersensitive effects.2% azone+1% volatile oil had more powerful enhancement effects.after 12 h,amont of drug delivery/unit area Q/(?g/cm2) and absorption percentage Q% of triptolide and meloxican in the preparation reached a platea conventration.The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin,and there is a good dermal absorption.
