Drug delivery of sinomenine hydrochloride floating and pulsatile release tablet
- VernacularTitle:盐酸青藤碱漂浮型脉冲释放片的释药机理研究
- Author:
Yaling WU
;
Yanna GENG
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
sinomenine hydrochloride;
floating and pulsatile release tablets;
in vitro drug delivery
- From:
Chinese Traditional Patent Medicine
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare a phase-specific drug delivery system with floating and pulsatile release of sinomenine hydrochloride and evaluate in vitro drug release behavior. METHODS: The floating and pulsatile-release of coat-core tablets were prepared by press-coated technics.The effects of factors influencing release characteristic of the drug were investigated by dissolution test,and to elucidate the mechanism of drug release of the tablets with erosion and water-uptake test. RESULTS: The tablets had typical floating and pulsatile release properties with a lag time rapid release.The lag-time was shortened with the increase of expansion ratio of tablet core and rotation speed of stirrer.The lag-time was prolonged with the increase of pH and ionic strength of dissolution media. CONCLUSION: The tablet could float and rapidly release drug at the predetermined time.
