Experimental Study on the Potential Changing Mechanism of cAMP in Asthenia Cold Syndrome Rats
- VernacularTitle:虚寒状态大鼠cAMP变化机制的实验研究
- Author:
Min LI
;
Bing ZHANG
;
Xiaoqing LIU
- Publication Type:Journal Article
- Keywords:
asthenia cold syndrome;
cAMP;
AC;
ATP;
endocrine hormone;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of endocrine, cAMP and potential mechanism in asthenia cold syndrome rats. Method The rats were randomly divided into normal group and asthenia cold model group. The model group were treated with intramuscular injection of hydrocortisone for 14 days, and the normal group with NS. The content of cyclic adenosine monophosphate (cAMP) and adenylate cyclase (AC), triiodothyronine (T3), thyroxine (T4), dopamine (rT3), cortisol (COR), cyclic guanosine monophosphate (cGMP) was detected by radioimmunoassay (RIA). The content of adenosine triphosphate (ATP) was detected by chemiluminescence. Result The content of T3, T4, rT3, COR, cAMP were decreased, the activity of AC was decreased, the conent of ATP was increased. Conclution The function of the endocrine system was suppressed in asthenia cold rats, which can down-regulate cAMP and lead to asthenia cold syndrome.
