Study on Active Sites of Anti-inflammatory and Analgesic in Jinxuan Zhike Xunxi San
- VernacularTitle:金玄痔科熏洗散的抗炎镇痛活性物质筛选研究
- Author:
Wenying ZHANG
;
Lu ZHOU
;
Li WEN
- Publication Type:Journal Article
- Keywords:
Jinxuan Zhike Xunxi San;
anti-inflammatory and analgesic;
the material of supercritical CO2 extract;
the saponins and flavonoids extract;
minerals
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explain the material foundation of anti-inflammatory and analgesic effects of Jinxuan Zhike Xunxi San. Methods The foot swelling experiments in rat and xylene-induced ear edema experiments in mouse were adopted to observe the anti-inflammatory effects of the material extracted and purified from Jinxuan Zhike Xunxi San. The hot plate-induced pain experiment for studying the analgesic effect was established. Results The material of supercritical CO2 extract, saponins and flavonoids extract and minerals in Jinxuan Zhike Xunxi San had a inhibiting effect on egg-induced foot swelling in rat, saponins and flavonoids extract had a distinct inhibiting effect on xylene-induced ear edema in mouse. Every extract had obvious analgesic effects on hot plate-induced pain and significantly increased the threshold of pain. Conclusion The active ingredient groups of Jinxuan Zhike Xunxi San are the material of supercritical CO2 extract, saponins and flavonoids extract and minerals.
