Effects of atorvastatin on serum levels of IL-1?,TNF-? and OX-LDL in cerebral spontaneous hemorrhage
- VernacularTitle:阿托伐他汀对急性自发性脑出血患者血清IL-1?、TNF-?和OX-LDL水平的影响
- Author:
Jiaze TAN
- Publication Type:Journal Article
- Keywords:
Cerebral spontaneous hemorrhage;
Atorvastatin;
Inflammation;
Oxidative stress
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the in fluence of atorvastatin on serumlevels of IL-1?,TNF-?,OX-LDLand serumlipid in cerebral spontaneous hemorrhage to study its protection mechanisms for cerebral spontaneous hemorrhage.Methods:Sixty patients with cerebral hemorrhage were divided into normal serum lipid level group with cerebral spontaneous hemorrhage(A),and higher serum lipid level group with cerebral spontaneous hemorrhage(AH),normal serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment(AT),and higher serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment(AHT).Neurological deficiency score was examined.IL-1?,TNF-?,and OX-LDL were measured by enzyme linked immunosorbent assay;and serum lipid level was measured by biochemistry.Results:The serum levels of IL-1?,TNF-?,and OX-LDL in AT group were significantly decreased compared with those of A group(P0.05);The serum levels of IL-1?,TNF-?,and OX-LDL in AHT group were significantlylower than those in AH group,and compared with those at 2w,all the levels at 4wand 6wwere significantly lowe(rP
