Effects and Mechanism of Polysaccharide of Sijunzi Decoction on sIgA in Intestine of Immune Suppression Mice
- VernacularTitle:四君子汤总多糖对免疫抑制小鼠肠道sIgA的影响及其机制研究
- Author:
Dapeng ZHANG
;
Lian ZHOU
;
Zhiming ZHANG
;
Qing WANG
;
Peixun WANG
- Publication Type:Journal Article
- Keywords:
Polysaccharide of sijunzi Decoction;
Intestinal mucosa;
sIgA;
CD3;
CD19;
TLR4;
Mice
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily study effects of polysaccharide of Sijunzi Decoction (SD) on the function of intestinal mucosal humoral immune. Methods NIH mice were equally randomized into 4 groups:normal control group,model group,SD polysaccharide (SDPS) group,and SD free proteoglycan (SDFP) group. The intestinal sIgA content was detected by ELISA. The phynotype of Peyer's nodel cells was examined with flow cytometer. Immunohistochemistry was used to detect the expression of TLR4 receptor in the intestine. Results Compared to the normal control group,SDPS and SDFP group,the concentration of sIgA was significantly decreased in the model group (P
