Therapeutic Mechanism of Zhixie Tuire Tablet for Rotavirus-induced Diarrhea
- VernacularTitle:止泻退热片治疗轮状病毒感染性腹泻的机制研究
- Author:
Mengmeng YANG
;
Jiabo LUO
;
Yan ZHANG
;
Wen CHEN
- Publication Type:Journal Article
- Keywords:
Zhixie Tuire Tablet;
Rotavirus;
Diarrhea;
SGLT1 mRNA;
PGE2;
Neonatemice
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe into the therapeutic mechanism of Zhixie Tuire Tablet (ZTT) for rotavirus-induced diarrhea. Methods We established the 4-day old Kunming neonatal mice model by infecting group A G3 type of rotavirus,and then gave the inoculated mice with ZTT at the dose of 0.78 g/kg for three days. Fluorescent quantification PCR method was used to detect the changes of sodium glucose transporter SGLT1 mRNA level and radio-immunity method was used for the examination of PGE2 level in neonatal mice small intestine. Results SGLT1mRNA level was lower in ZTT group than that in the normal group,the difference being significant (P 0.05). PGE2 level in ZTT group was higher than that in the normal group,but lower than that in the model group (P
