Anti-inflammatory Action and Pharmacodynamics of Liushen Cataplasm
- VernacularTitle:六神巴布剂抗炎药效动力学的研究
- Author:
Bin YU
;
Zhenghong WU
;
Yan LI
;
Yingyu WANG
;
Wei GAO
;
Yong LIU
- Publication Type:Journal Article
- Keywords:
Liushen Cataplasm;
Anti-inflammation;
Pharmacodynamics
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To sutdy the anti-inflammatory action and pharmacodynamics of Liushen Cataplasm (LC). Methods The anti-inflammatory action of LC was observed on mice models of xylene-induced ear swelling and on the rat models of carrageenan-induced pedal swelling. With the decrease of pedal swelling as the parameter,the pharmacodynamics of LC was studied. The apparent parameters of pharmacodynamics were estimated based on the time-effect curve. Results LC showed a potent anti-inflammatory effect. The effect-time curve can be described by the one-compartment model. The main pharmacodynamic parameters were as follows:t1/2(Ka)=2.11727h,t1/2(Ke)=3.13464h,AUC=3.33131 mg?kg?h-1,respectively. Conclusion Liushen Cataplasm shows a potent anti-inflammatory effect. The effect-time curve can be described by the one-compartment model.
