Study on Aorui Gel in Preventing Esophageal Mucosa from Injury in Reflux Esophagitis Rats
- VernacularTitle:奥瑞凝胶抗反流性食管炎模型大鼠食管黏膜损伤的实验研究
- Author:
Xiaoxiao WANG
;
Ming WEI
;
Fei DUAN
;
Juan LIU
- Publication Type:Journal Article
- Keywords:
Aorui Gel;
Reflux Esophagitis;
Animal Models;
Mucosal injury
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe protective and repairing effect of Aorui Gel on esophageal mucosa injury in reflux esophagitis rats. Methods Rat models of reflux esophagitis were established by partial pylori ligation plus cardiomyotomy. Model control group,low-,middle-and high-dose Aorui Gel groups,positive control group,excipient control group and sham operation group were set up. Rats were treated with the corresponding drugs 7 days after operation. After treatment for 14 days,the rats'general state,and macroscopic features and pathological features of esophageal mucosa were compared. Results Macroscopic features and pathological features of esophageal mucosa in Aorui Gel groups differed from those in the model control group,inflammation of esophageal mucosa in Aorui Gel groups was alleviated,and pathological features were relieved and arrived to the normal state. Conclusion Aorui Gel can alleviate esophageal mucosa injury in reflux esophagitis rats,indicating that Aorui Gel has protective and repairing effect on esophageal mucosa injury.
