Research of Intervention with Electroacupuncture Through Regulating MAPK/ERK Pathway for Cerebral Ischemia Rats
- VernacularTitle:针刺调节MAPK/ERK通路对脑缺血模型大鼠的干预作用
- Author:
Zhonghua YANG
;
Nenggui XU
;
Wei YI
;
Tao YU
;
Zhengni DONG
- Publication Type:Journal Article
- Keywords:
CEREBRAL ISCHEMIA/ acup-mox therapy;
BRAIN/pathology;
DISEASE MODELS,ANIMAL;
RATS;
POINT GV20(BAIHUI);
POINT GV14(DAZHUI)
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the intervention with electroacupuncture(EA) through regulating protein kinase(MAPK/ERK) pathway for cerebral ischemia rats.Methods SD rats were randomized into pseudo-operation group,model group and EA group.And the three groups were divided into 2-hour,one-day and 3-day subgroups according to the observation time.Focal cerebral ischemia(FCI) rat models were established by middle cerebral artery occlusion(MCAO) with heat-coagulation method.EA group received EA on Baihui(GV20) and Dazhui(GV14),qd,for 2 hours,one day and 3 days respectively.The learning and memory abilities of the rats in Y maze test and their neuroethological score were observed.Immunohistochemical method was used to observe the expression of phosphorylated extracellular signal-regulated kinase(p-ERK) after ischemia in CA1 area and CA3 area.Results In the model group,the neuroethological score was markedly increased,time for arriving the safe area in Y maze was prolonged(P
