An investigation on the in vitro release behavior of TCM components in different pressure sensitive adhesives
- VernacularTitle:止痛活血压敏胶贴片中有效成分的体外释放研究
- Author:
Mingming CHANG
;
Yuming SUN
;
Qing WANG
;
Yong QIAN
;
Xin ZHANG
;
Tianfu WANG
- Publication Type:Journal Article
- Keywords:
acrylic ester;
thermosol;
in vitro release;
zhitong huoxue plaster;
tetrahydropalmatine;
aconitine;
paeoniflorin;
ginsenoside Rg_1
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To examine the effect of acrylic ester and thermosol respectively as pressure sensitive adhesive matrix of zhitong huoxue extract(Rhizoma Corydalis,Radix aconiti,Radix Paeoniae alba,Radix et notoginseng ginseng,etc)on the dissolution of effective constituent from zhitong huoxue extract.METHODS:The in vitro release experiment was carried out on Permcell diffusion cell,HPLC method was applied to determining the cumulative elease rate of tetrahydropalmatine,aconitine,paeoniflorin and ginsenoside Rg_1 from zhitong huoxue pressure sensitive adhensive.RESULTS:The acrylic ester matrix had sound controlled release profile in vitro of alkaloid components.In KT-A thermosol matrix,the in vitro release rate proved to be inversely proportional to the molecular weight(R= 0.91)of the effective constituents,while the 2501 s matrix presented a steadily cumulative release rate over 12 h(30%-43%).CONCLUSION:Good release rates are observed with effective constituent with small molecular weight,adhesive composition of matrix has an obvious effect on the in vitro release behavior of zhitong huoxue extract.
