Effects of Shoutaiwan on the STAT Signal Transduction Pathway of CD_4~+ T Cells in Maternal-fetal Interface of Mice with Recurrent Spontaneous Abortion
- VernacularTitle:寿胎丸对反复自然流产小鼠母胎界面CD_4~+ T细胞STAT信号转导途径的影响
- Author:
Dongmei HE
;
Zhaoling YOU
;
Maohua LAI
- Publication Type:Journal Article
- Keywords:
Shoutaiwan;
recurrent spontaneous abortion;
signal transduction;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Shoutaiwan on the STAT signal transduction pathway of CD4+ T cells in maternal-fetal interface of mice with recurrent spontaneous abortion(RSA).Methods CBA/J?BALB/C mating combination and CBA/J?DBA/2 mating combination were used as normal pregnancy and RSA model respectively.Mice with RSA were randomly assigned to model group and Shoutaiwan group.After 14 days of administration,the STAT signal transduction pathway of CD4+ T cells in mice decidual and placental tissues were detected by Springbio 720 antibody microarrays.Results Shoutaiwan could increase the phosphorylation level of STAT3 and STAT6 protein in the STAT signal transduction pathway.At the same time,Shoutaiwan could decrease the phosphorylation level of STAT1 protein.Conclusion The activation of STAT3 and STAT6 signal transduction pathway might play a important role in the therapy of RSA by Shoutaiwan.
