A novel derivative of ginsenoside sapogenin and its activity against HL-60 cells
- VernacularTitle:一个新颖的人参皂苷元衍生物及其抗HL-60肿瘤细胞活性
- Author:
Huifeng LI
;
Hongzhu GUO
;
Dean GUO
- Publication Type:Journal Article
- Keywords:
1′-hydroxy ethanedioxy protopanaxatriol;
ginsenoside sapogenin derivative;
HL-60 cells
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the derivatives of ginsenoside sapogenins and their activities against HL-60 cells.Methods The total ginsenoside extract was treated by Smith degradation.All products were isolated by silica gel chromatography and purified by preparative HPLC.On the basis of 1D and 2D NMR data,structures were elucidated.The activity against HL-60 cells was measured by MTT method.Results Three compounds were isolated and identified as 20(S)-protopanaxadiol(PD),20(S)-protopanaxatriol(PT),and 24,25-en-3?,6?-dihydroxy-12,20-(1′-hydroxy) ethanedioxy-dammarane(1).Conclusion Compound 1,named 1′-hydroxy ethanedioxy PT,is a novel derivate of sapogenin with higher inhibitory activity against HL-60 cells than PD and PT.
