Effect of irbesartan on the expression of PPAR-? and ventricular remodeling in rats with myocardial infarction
- VernacularTitle:厄贝沙坦对大鼠梗死心肌PPAR-?表达及心室重塑的影响
- Author:
Jun LIU
- Publication Type:Journal Article
- Keywords:
PPAR-?;
Myocardial infarction;
Irbesartan;
Ventricular remodeling
- From:Journal of Chongqing Medical University
2007;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expreesion of PPAR-? in the left ventricular myocardium in rats with myocardial infarction,and to investiagate whether the mechanism of Irbesartan reversing the ventricular remodeling is related to PPAR-?.Methods:Myocardial infarction models were successfully induced by ligation of anterior descending coronary artery.24 h later the survivors were randomly divided into 3 groups.① MI group;② Irbesartan group 75 mg/(kg?d);③ The rats with sham ligation formed Sham group.After 6 weeks,the expreesion of PPAR-?,the ratio of LV weight to body weight(LVWI),cross-section area(CSA)of left ventricular myocardium were examined.The collagen volume fraction(CVF) were analyzed by PSR dyeing.Results:In MI group,compared with those in Sham group,the expreesion of PPAR-?mRNA and protein in the left ventricular myocardium decraced significantly,but the LVWI,CSA and the CVF in non-infarcted zone increased.Compared with those in MI group,in Ire group,the expreesion of PPAR-?mRNA and protein in cadiocyte incraced,while the LVWI 、CSA and the CVF in non-infarcted zone decreased.Conculusion:The expression of PPAR-? is down-regulated in the left ventricular myocardium with myocardial infarction,Irbesartan reverses the left ventricular remodeling possibly by up-regulating and activating PPAR-?.
