Association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer
- VernacularTitle:mdr1C3435T基因多态性与卵巢癌遗传易感性关系研究
- Author:
Lifang MA
- Publication Type:Journal Article
- Keywords:
Ovarian cancer;
mdr1C3435T gene polymorphism;
Genetic predisposition to disease
- From:
Journal of Chongqing Medical University
2007;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer.Methods:mdr1C3435T gene was determined by PCR-RFLP method in 135 ovarian cancer patients(cases group) and 146 healthy women(control group).Results:The frequency of C/C genotype in cases group(30.37%) was significantly lower than that in controls(47.95%),and the frequencies of T/C(44.44%)and T/T(25.19%) respectively in cases group were significantly higher than those in controls(T/C38.35%,T/T13.7%).The frequency of mdr1C3435T null genotype in cases group(25.19%) was higher than that in control group(13.7%).Compared with controls,the susceptibility of ovarian cancer with the T/T genotype was increased by 2.121-fold.There was significant difference in frequency of mdr1C3435T null and nonnull genotype between cases and controls of average age(P
