Coating technique of pH-time lag colon-specific matrine delivery mini-pill
- VernacularTitle:pH-时滞型苦参结肠靶向微丸包衣工艺研究及体外评价
- Author:
Xiaofang LI
;
Jiao WANG
;
Ke LI
;
Xiaoyong CAO
;
Tingting XIONG
;
Yu XUE
- Publication Type:Journal Article
- Keywords:
pH time lag colon-specific matrine delivery mini-pill;
coating technique;
evaluation in vivo
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the coating technique of pH-time lap colon-specific matrine delivery mini-pill consisted of the time lag release coating (inner layer) and enteric coating (out layer). METHODS:To filter the coating composition based on the index of dissolution of matrine and oxymatrine in vitro and the appearance rating of miui-pill. RESULTS:4 The coating composition of inner layer was the alcoholic solution,consisted of 2% EC,0.4% DEP and 2% talc powder. Then the coating composition of out layer was the alcoholic solution consisted of 5% Eudragit S100,3% talc powder and 0.5% TEC. The dissolution tests in vitro indicated that matrine and oxymatrine were not dissolved in the simulated gastric juice in 2 h. The accumulative amount of matrine and oxymatrine were less than 15% in the simulated intestinal fluid in 4 h. The amount of matrine and oxymatrine were 80.7% and 83.5% in the simulated colon juice in 2 h. CONCLUSION:The mini-pill could achieve the goal of delivering in the specific colon.
