Effect of Invigorating Spleen,Clearing Heat and Eliminating Stasis Drugs on EGF and EGFR Expression in Rat Model of Gastric Ulcer
- VernacularTitle:健脾清热化瘀药对胃溃疡大鼠表皮生长因子及其受体表达的影响
- Author:
Yongxin BAO
;
Guanhua LV
;
Jinting ZHAO
- Publication Type:Journal Article
- Keywords:
invigorating spleen;
eliminating stasis drugs;
EGF;
EGFR;
QOUH;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of invigorating spleen, clearing heat and eliminating stasis drugs on QOUH of gastric mucosa and expression of EGF and EGFR in rat model of gastric ulcer. Methods The rat model of gastric ulcer was constructed by injection of acetic acid. The rats were randomly divided into model group, ranitidine group, invigorating spleen group, clearing heat group, eliminating stasis group, complex prescription group and normal control group. The ulcer index (UI), regenerate mucosal thickness, lamina muscularis mucosal width were observed by HE, and the level of EGF was detected by ELISA. The expression of EGFR in the mucosa around the ulcer was detected by SABC kit immunohistochemical method. Results Compared with model group, the regenerate mucosal thickness, lamina muscularis mucosae defect width and UI in invigoraing spleen, clearing heat, elimianting stasis and complex prescription groups were different significantly (P
