Analysis of Factors Affecting Adverse Reactions of Statins
- VernacularTitle:他汀类药物不良反应及相关因素分析
- Author:
Shen CAI
;
Yingli ZHENG
;
Li FANG
- Publication Type:Journal Article
- Keywords:
Statins;
Adverse drug reactions;
Related factors;
Pharmacoepdemiology
- From:
Chinese Journal of Pharmacoepidemiology
2005;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the regularity of adverse drug reactions induced by statin.Method:82 cases from published articles were retrieved from 1998 to 2008.According to the given standard,the data were statistically analyzed. Result:77 articles carried 82 case reports concerning statins inducing ADRs in the period of 10 years.52 cases were caused by simvastatin.ADRs of statins could involve multiple organs and systems,mainly myopathys.Severe reaction could result in renal failure and even death.Conclusion:A rational use of statins should be strengthened in the clinical practice and strict monitoring in order to prevent and reduce the occurrence of serious adverse drug reactions.
