Intenstinal absorption mechanism and in vitro-in vivo correlation of norcantharidin nanoparticles
- VernacularTitle:去甲基斑蝥素纳米粒肠道吸收的体内外相关性研究
- Author:
Xiaoyan CHEN
;
Yang LIU
;
Wei ZHANG
;
Yongyan BEI
;
Jingyu XU
;
Wenjuan WANG
;
Xuenong ZHANG
- Publication Type:Journal Article
- Keywords:
norcantharidin;
nanoparticle;
accumulation release;
absorption kinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The absorption of NCTD was a first-order process with passive diffusion mechanism.The absorption law in vivo was the same as in vitro,the correlation coefficient between them was 0.999 4.Conclusion NCTD-CS-NP could improve the absorption of NCTD in rat small intestine.NCTD is well absorbed at the superior and middle segments of intestine.The concentration of NCTD has no distinctive effect on the absorption kinetics.The release of drug in vitro and its uptake is well correlated.
