Effect of Shuxuetong injection on the expressions of TGF-?_1 and Col-IV in renal tissues in diabetic rats
- VernacularTitle:疏血通注射液对糖尿病大鼠肾脏TGF-?_1及Col-Ⅳ表达的影响
- Author:
Wenjuan JIANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Shuxuetong injection;
Transforming growth factor?1;
Collegen typeⅣ
- From:
Journal of Chongqing Medical University
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of Shuxuetong injection on the urine protein excretion changes and expressions of transforming growth factor ?(1TGF-?1)and collegen type Ⅳ(Col-Ⅳ)in renal tissues in diabetic rats.Methods:Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin(STZ).Rats were randomly divided into control group,untreated DN group,Shuxuetong group and Benazepril group.Urinary albumin excretion rate(UAER),?2-microglobulin(?2-MA)and KW/BW(kidney weight/body weigh)were determined 8 weeks later.The expressions of TGF-?1 and Col-Ⅳ in renal tissues were determined by using immunohistochemical methods.Results:After interference,compared with the untreated DN group,UAER,?2-MA,KW/BW in the Shuxuetong group were significantly down-regulated(P
